Transplant Immunology Decision Support System TRIMMUS

The TRIMMUS project (Transplant Immunology Decision Support System) fulfills the goals of the TAČR KAPPA program by expanding the cooperation between the Czech company Steiner, s.r.o. and the Department of Immunology, Oslo University Hospital, Norway.

The aim of the project is to develop a software solution completely covering the workflow of the Transplant Immunology laboratory at Oslo University Hospital to abandon paper communication and routine manual procedures, improve patient safety, provide the best possible care, meet accreditation requirements, improve information flow, increase data safety, speed up work procedures and improve decision-making

Project No.: TO01000057

Project Promoter: Steiner, s.r.o

Project Partner: Oslo University Hospital

Contact Person: Mgr. Ing. David Steiner, MBA, Ph.D.



Transplant immunology is the medical science ensuring optimal matching of donor and recipient before allogeneic transplantation of cells, tissues and solid organs. Allogeneic transplantation is a complex process involving transplant immunology, donor availability, matching criteria, coordination and specialised medical personnel. Oslo University Hospital requires a laboratory information system for transplant immunology, integrated with decision support systems, work-up mapping and post-transplant follow-up registries.

Our team combines IT skills and HLA matching experience in Steiner, s.r.o., with laboratory and clinical expertise from Oslo University Hospital. Since all transplant immunology, organ transplantation and HLA-matching for stem cell transplantation in Norway are performed in one center, we have an unique opportunity to develop and test the effect of our new TRansplant IMMUnology decision support System (TRIMMUS), covering all steps from registering samples in the Transplant Immunology laboratory via decision support tools for combining available donors with recipients to an evaluation of long-term results after allogeneic transplantation. TRIMMUS will replace manual data transfer, thus reducing the risk of human errors. TRIMMUS will also present all relevant data and run algorithms to facilitate quick and appropriate counselling and decision-making, thus providing the best possible care.

Steiner supplies software technology, and Oslo University Hospital provides the medical expertise to develop algorithms and evaluate the performance of each algorithm as well as the entire solution. Results of post-transplant outcome will be used to improve pre-transplant matching algorithms.



Today is interesting not only by the numbers that are listed in the calendar, but also by the fact that we have improved the conditions for testing the functionality of the future application. Steiner has set up a new virtual server with significantly higher performance than the current one, so we can perform more automated tests every day. At Oslo University Hospital, the current data from the production server has been copied to the development environment, and the functionality of the application and the new algorithms will be verified by bioengineers and doctors involved in the project. At the same time, we will verify the correctness of data migration to the current database schema.


After ten months of intensive work since the start of the project, the implementation phase of the first tasks of the new TRIMMUS product (Transplant Immunology Decision Support System) was completed. In the field of bioinformatics research and development, an algorithm for searching for platelet donors and algorithms for determining PRA, CRF and EPF were completed. In the field of software research and development, several hundred changes to the user interface have been made, and more than 2,000 automated tests have been created to verify the correct functionality of the entire application.



The Transplant Immunology Decision Support System (TRIMMUS) project benefits from a € 1.2 Mil. grant from Iceland, Liechtenstein and Norway through the EEA Grants and the Technology Agency of the Czech Republic within the KAPPA Programme.