Trimmus
The TRIMMUS project (Transplant Immunology Decision Support System) fulfills the objectives of the TAČR KAPPA program by expanding cooperation between the Czech company Steiner, sro and the Department of Immunology of the University Hospital in Oslo, Norway.
The aim of the project is to develop a software solution that fully covers the workflows of the Transplant Immunology Laboratory of Oslo University Hospital, so that it is possible to abandon paper-based communication methods in routine manual procedures, increase patient safety while providing the best possible care, meet accreditation requirements, improve information flow and data security, and last but not least, speed up workflows and improve decision-making.
- Project number: TO01000057
- Project leader: Steiner, sro
- Project partner: Oslo University Hospital
- Contact person: M.Sc. Ing. David Steiner, MBA, Ph.D.
Project with support
Project content
Transplant immunology is the medical science that ensures optimal donor-recipient matching prior to allogeneic transplantation of cells, tissues, and solid organs. Allogeneic transplantation is a complex process involving transplant immunology, donor availability, matching criteria, coordination, and specialized medical personnel. Oslo University Hospital requires a laboratory information system for transplant immunology, integrated with decision support systems, workflow mapping, and post-transplantation follow-up registries.
Our team combines the IT skills and HLA experience of Steiner, sro with the laboratory and clinical knowledge of the medical staff of Oslo University Hospital. Since all transplantation immunology, organ transplantation and HLA matching for stem cell transplantation in Norway are carried out in one center, we have a unique opportunity to develop and test the benefits of a new decision support system in transplantation immunology (TRIMMUS). It covers all steps from sample registration in the transplantation immunology laboratory through decision support tools for matching available donors with recipients to the evaluation of long-term outcomes after allogeneic transplantation. TRIMMUS will replace manual data transfer, reducing the risk of human error. TRIMMUS will also present all relevant data and run algorithms to facilitate rapid and appropriate counseling and decision-making, thereby providing the best possible care.
Steiner is providing the software technology and Oslo University Hospital is providing the medical expertise for algorithm development and performance evaluation of each algorithm and the overall solution. The outputs of the post-transplant conclusions will be used to improve the pre-transplant search algorithms.
Thanks
The Transplant Immunology Decision Support System (TRIMMUS) has received €1.2 million in support from Iceland, Liechtenstein and Norway through EEA funds and the Technology Agency of the Czech Republic under the KAPPA programme.
Expected completion:
News
30.4.2024
We are pleased to announce the successful completion of the Transplant Immunology Decision Support System (TRIMMUS) project, a software solution designed to improve workflows and decision-making processes in transplant immunology departments. This project has led to improved workflows in organ and tissue transplantation.
The TRIMMUS system is a comprehensive platform designed to replace manual, paper-based procedures with a fully digital and efficient workflow. It includes advanced bioinformatics algorithms such as PRA, CRF and EPF to optimize the identification of suitable donors, increase patient safety and improve clinical outcomes.
18. – 21. 6. 2023
The TRIMMUS (Transplant Immunology Decision Support System) project was presented as a poster session at the recent World Marrow Donor Association (WMDA) meeting. This prestigious event brought together world leaders in transplant immunology and donor registry management and provided an excellent platform to showcase the innovations of the TRIMMUS project.
The poster highlighted the key features of the TRIMMUS system, including its automated donor search algorithms, advanced HLA typing tools, and its ability to optimize the decision-making process before and after transplantation. The conference provided us with the opportunity to discuss with colleagues from the transplantation community future collaborations and opportunities for integrating the TRIMMUS system into their laboratories.
22.02.2022
To date, we have improved the conditions for testing the functionality of the future application. A new virtual server with significantly higher performance than the current one has been set up on the Steiner side, so we will be able to perform a larger number of automated tests every day. At Oslo University Hospital, current data from the production server has been copied to the development environment, and the functionality of the application and new algorithms will be verified on it by bioengineers and doctors involved in the project. At the same time, we will use this opportunity to verify the correctness of the data migration to the current database schema
07.10.2021
After ten months of intensive work since the start of the project, the implementation phase of the first tasks of the new product TRIMMUS (Transplant Immunology Decision Support System) has been completed. In the area of bioinformatics research and development, the algorithm for searching for platelet donors and the algorithms for determining PRA, CRF and EPF have been completed. In the area of software research and development, several hundred changes to the user interface have been made, and more than 2000 automated tests have been created for machine verification of the correct functionality of the entire application.